5-[4-(4-Oxo-piperidin-1-yl)-benzyl]-thiazolidine-2,4-dione → HCID 131723780, compound

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Reaction Steps

The title compound was prepared from 5-[4-(4-oxo-piperidin-1-yl)-benzyl]-thiazolidine-2,4-dione (which was obtained in Example 38) and propane-2-sulfonic acid [5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-amide (which was obtained in Example 27) according to the procedure of Example 73 as a white solid; mp>175° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.25(d, J=6.8 Hz, 6 H), 1.30–1.55 (m, 2 H), 1.80–2.00(m, 2 H), 2.60–3.70(m, 9 H), 4.47(dd, J=9.7, 3.9 Hz, 1 H), 4.58(dd, J=8.7, 3.4 Hz, 1 H), 6.75–6.90(m, 3 H), 6.90–7.10(m, 3 H), 7.26(d, J=2.0 Hz, 1 H); MS (ES) m/z: 563.0 (MH+, 100%); HRMS Calcd. for C26H35N4O6S2 (MH+): 563.1992. Found: 563.1985.

Provenance & Evidence