(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 178505034, compound

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Reaction Steps

The title compound was prepared from 1-[4-(1H-tetrazol-5-yl)-phenyl]-piperidin-4-one (which was obtained in Example 47) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 73 as a white solid; mp>175° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.65 (m, 2 H), 1.90–2.10 (m, 2 H), 2.70–3.10 (m, 5 H), 2.95 (s, 3 H), 3.70–3.85 (m, 2 H), 4.69 (dd, J=9.3, 3.0 Hz, 1 H), 6.89 (d, J=8.3 Hz, 1 H), 6.97 (d, J=8.9 Hz, 2 H), 7.06 (dd, J=8.3, 2.0 Hz, 1 H), 7.24 (d, J=2.0 Hz, 1 H), 7.80 (d, J=8.9 Hz, 2 H); MS (ES) m/z: 474.1 (MH+); HRMS Calcd. for C21H28N7O4S (MH+): 474.1918. Found: 474.1912.

Provenance & Evidence