Sodium Hydroxide → HCID 10186814, compound

Participants

Reaction Steps

The title compound was prepared from ethyl [5-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}phenyl)-1H-tetraazol-1-yl]acetate (which was obtained in Example 98) by NaOH hydrolysis as an off-white solid; mp>210° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.30–1.50 (m, 2 H), 1.80–2.00 (m, 2 H), 2.60–3.50 (m, 5 H), 2.92 (s, 3 H), 3.70–3.85 (m, 2 H), 4.50–4.60 (m, 1 H), 4.70–4.80 (m, 2 H), 6.84 (d, J=8.2 Hz, 1 H), 6.95–7.05 (m, 3 H), 7.20 (d, J=1.6 Hz, 1 H), 7.66 (d, J=8.7 Hz, 2 H); MS (ES) m/z: 530.2 (M−H)−; HRMS Calcd. for C21H28N7O4S (M−H)−: 530.1827. Found: 530.1827.

Provenance & Evidence