Sodium Hydroxide → HCID 9837030, compound

Participants

Reaction Steps

Aqueous sodium hydroxide (5N, 11 mL) was added to a solution of (1S)-2-bromo-1-[2-(trifluoromethyl)-1,3-thiazole-4-yl]ethanol (which was obtained in Example 103) (1.52 g, 5.5 mmol) in tetrahydrofuran (6 mL). The mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with H2O (30 mL) and extracted with dichloromethane. The organic extracts were washed with H2O and brine, and dried over MgSO4. Evaporation and purification by flash chromatography (hexanes/dichloromethane 6/4) gave a clear oil (1.33 g, 74% yield); MS (ES) m/z: 196 (MH+); 1H NMR (400 MHz, CDCl3) δ 3.09 (m, 1H), 3.19(m, 1H), 4.11(m, 1H), 7.48 (s, 1H).

Provenance & Evidence