HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-hydroxypyridine → 2-Methyl-5-[(oxiran-2-yl)methoxy]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| Product | 2-Methyl-5-[(oxiran-2-yl)methoxy]pyridine | HCID 22220235 | — |
Reaction Steps
The title compound was prepared from 6-methyl-3-pyridinol and (2S)-oxiranylmethyl 3-nitrobenzenesulfonate in substantially the same manner as described in Example 123. The product was obtained as a brown oil; 1H NMR (400 MHz, DMSO-d6) δ 2.38 (s, 2.38, 1H), 2.68–2.70 (m, 1 H), 2.81–2.84 (m, 1 H), 3.30–3.34 (m, 1 H), 3.83–3.87 (m, 1 H), 4.34–4.38 (m, 1 H), 7.15–7.17 (m, 1 H), 7.28–7.31 (m, 1 H), 8.15–8.16m (m, 1 H); MS (ES) m/z: 165 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022716B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-ac65efd2f20d424bae644e26ea393301 |
| Source note | uspto-grants-2006_04 |