3-[(2S)-oxiran-2-yl]pyridine → (S)-2-amino-1-(pyridin-3-yl)ethanol

Participants

Reaction Steps

The title compound was prepared from 3-[(2S)-oxiranyl]pyridine (which was obtained in Example 129) and saturated ammonium methanol in substantially the same manner, as described in Example 124. The product was obtained as a brown oil; 1H NMR (400 MHz, DMSO-d6) δ 1.60 (brs, 2 H), 2.59–2.71 (m, 2 H), 4.47–4.50 (m, 1 H), 5.20 (brs, 1 H), 7.31–7.34 (m, 1 H), 7.68–7.71 (m, 1 H), 8.42–8.43 (m, 1 H), 8.50–8.51 (m, 1 H); MS (ES) m/z: 139 (MH+).

Provenance & Evidence