L-Leucine, ethyl ester, hydrochloride (1:1) → 4-Methyl-(2S)-2-[4-(4-oxo-piperidin-1-yl)-benzoylamino]-pentanoic acid ethyl ester

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidin-1-yl)-benzoic acid (which was obtained in Example 151) and L-leucine ethyl ester hydrochloride according to the procedure of Example 154 as a white flake; 1H NMR (300 MHz, CDCl3) δ 0.99(t, J=6.2 Hz, 6 H), 1.30(t, J=7.1 Hz, 3 H), 1.60–1.80(m, 3 H), 2.56(t, J=6.0 Hz, 4 H), 3.72(t, J=6.0 Hz, 4 H), 4.22(q, J=7.1 Hz, 2 H), 4.80–4.90(m, 1 H), 6.42(d, J=8.2 Hz, 1 H), 6.94(d, J=7.0 Hz, 2 H), 7.77 (d, J=7.0 Hz, 1 H); MS (ES) m/z: 361.3 (MH+); HRMS Calcd. for C20H28N2O4(M+): 360.2049. Found: 360.2081.

Provenance & Evidence