Leucine methyl ester hydrochloride → HCID 69654989, compound

Participants

Reaction Steps

The title compound was prepared from 4-(4-oxo-piperidin-1-yl)-benzoic acid (which was obtained in Example 151) and L-leucine methyl ester hydrochloride according to the procedure of Example 154 as a gum; 1H NMR (300 MHz, CDCl3) δ 0.96(t, J=6.2 Hz, 6 H), 1.60–1.80(m, 3 H), 2.57(t, J=6.1 Hz, 4 H), 3.71(t, J=6.1 Hz, 4 H), 3.77 (s, 3 H), 4.80–4.90(m, 1 H), 6.40(d, J=8.2 Hz, 1 H), 6.94(d, J=7.0 Hz, 2 H), 7.75(d, J=7.0 Hz, 1 H); MS (ES) m/z: 347.4 (MH+); HRMS Calcd. for C19H26N2O4(M+): 346.1892. Found: 346.1881.

Provenance & Evidence