L-Leucinol → 4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-benzamide

참여 물질

역할	이름	HCID	투입량
반응물	L-Leucinol	HCID 111307	—
반응물	4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid	HCID 15948425	—
생성물	4-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-N-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-benzamide	HCID 69654770	—

반응 단계

The title compound was prepared from 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-benzoic acid (which was obtained in Example 150) (0.53 g, 2 mmol) and (S)-leucinol (0.30 g, 2.5 mmol) according to the procedure shown for Example 154 to give 0.53 g of a white solid; m.p. 90–91° C.; MS (ES) m/z: 363.3 (MH+); HRMS (ES) Calcd. for C20H31N2O4 (MH+): 363.2278. Found: 363.2275.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07022716B2
출처 데이터셋	uspto-grants-2006_04
ORD ID	ord-7611c6eda5a44d87a652a03d8be0208e
출처 메모	uspto-grants-2006_04