(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 21021937, compound

Participants

Reaction Steps

The title compound was prepared from (E)-3-[4-(4-oxo-piperidin-1-yl)-phenyl]-acrylic acid ethyl ester (which was obtained in Example 169) (0.27 g, 1.0 mmol) and N-[5-((1R)-2-Amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) (0.27 g, 1.1 mmol) according to the procedure shown for Example 180 to give 0.40 g of yellow solid; m.p. 103–106° C.; 1H NMR (DMSO-d6) δ 1.24 (t, 3 H), 1.20–1.45 (m, 2 H), 1.75–1.95 (m, 2 H), 2.55–2.95 (m, 5 H), 2.92 (t, 3 H), 3.67–3.85 (m, 2 H), 4.14 (q, 2 H), 4.46–4.50 (m, 1 H), 6.34 (d, 1 H), 6.96 (d, 1 H), 6.79–7.05 (m, 3 H), 7.05 (d, 1 H), 7.17 (d, 1 H), 7.56 (d, 2 H); MS (ES) m/z: 504.0 (MH+).

Provenance & Evidence