(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 86584567, compound

Participants

Reaction Steps

The title compound was prepared from N-benzyloxy-4-(4-oxo-piperidin-1-yl)-benzamide (which was obtained in Example 155) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 180 as a white solid; mp>70° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.2–1.40 (m, 2 H), 1.70–1.90 (m, 2 H), 2.50–2.95 (m, 5 H), 2.92 (s, 3 H), 3.70–3.85 (m, 2 H), 4.47 (dd, J=8.0, 4.2 Hz, 1 H),4.89 (s, 2 H), 6.81 (d, J=8.2 Hz, 1 H), 6.92 (d, J=9.0 Hz, 2 H), 7.00 (dd, J=8.2, 2.0 Hz, 1H), 7.18 (d, J=2.0 Hz, 1 H), 7.30–7.50 (m, 5 H), 7.60 (d, J=9.0 Hz, 2 H); MS (ES) m/z: 555.3 (MH+); HRMS Calcd. for C28H35N4O6S (MH+): 555.2272. Found: 555.2260.

Provenance & Evidence