HCID 10626009, compound → HCID 10627031, compound

Participants

Reaction Steps

The title compound was prepared from (2S)-2-[4-(4-oxo-piperidin-1-yl)-benzoylamino]-pentanedioic acid dibenzyl ester (which was obtained in Example 156) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 179 as a white solid; mp>230° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.60 (m, 2 H), 1.90–2.10 (m, 4 H), 2.31 (t, J=7.5 Hz, 2 H), 2.65–3.20 (m, 7 H), 3.00 (s, 3 H), 3.85–4.00 (m, 2 H), 4.25–4.35 (m, 1 H), 4.65–4.80 (m, 1 H), 6.88 (d, J=8.4 Hz, 1 H), 6.95 (d, J=8.7 Hz, 2 H), 7.08 (dd, J=8.4, 1.2 Hz, 1 H), 7.25 (d, J=1.8 Hz, 1 H), 7.74 (d, J=8.7 Hz, 2 H), 8.14 (d, J=7.2 Hz, 1 H); MS (ES) m/z: 579.1 (MH+); HRMS Calcd. for C26H35N4O9S (MH+): 579.1973. Found: 579.1955.

Provenance & Evidence