Ethyl {[4-(4-oxo-1-piperidinyl)benzoyl]amino}acetate → Ethyl[(4-{4-[((2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate

Participants

Reaction Steps

The title compound was prepared from ethyl {[4-(4-oxo-1-piperidinyl)benzoyl]amino}acetate (which was obtained in Example 161) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 180 as a white solid; mp>140° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20 (t, J=7.1 Hz, 3 H), 1.20–1.35 (m, 2 H), 1.75–1.90 (m, 2 H), 2.50–2.90 (m, 5 H), 2.90 (s, 3 H), 3.70–3.85 (m, 2 H), 3.93 (d, J=5.8 Hz, 2 H), 4.10 (q, J=7.1 Hz, 2 H), 4.47 (dd, J=7.9, 4.4 Hz, 1 H), 6.79 (d, J=8.3 Hz,1 H), 6.90–7.00 (m, 3 H), 7.16 (d, J=2.0 Hz, 1 H), 7.72 (d, J=8.9 Hz, 2 H), 8.58 (t, J=5.8 Hz, 1 H); MS (ES) m/z: 535.2 (MH+); HRMS Calcd. for C26H37N4O7S (MH+): 535.2221. Found: 535.2216.

Provenance & Evidence