Sodium Hydroxide → [(4-{4-[((2R)-2-Hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl)amino]-1-piperidinyl}benzoyl)amino]acetic acid

Participants

Reaction Steps

The title compound was prepared from ethyl [(4-{(4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate (which was obtained in Example 196) by sodium hydroxide hydrolysis as a white solid; mp>85° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.75–1.90 (m, 2 H), 2.55–2.90 (m, 5 H), 2.80 (s, 3 H), 3.49 (d, J=4.5 Hz, 2 H), 3.70–3.80 (m, 2 H), 4.43 (dd, J=7.9, 4.4 Hz, 1 H), 6.70 (d, J=7.4 Hz, 1 H), 6.81 (dd, J=7.4, 2.0 Hz, 1 H), 6.92 (d, J=8.9 Hz, 2 H), 7.12 (d, J=2.0 Hz, 1 H), 7.54 (t, J=4.5 Hz, 1 H), 7.64 (d, J=8.9 Hz, 2 H); MS (ES) m/z: 507.2 (MH+); HRMS Calcd. for C23H31N4O7S (MH+): 507.1908. Found: 507.1912.

Provenance & Evidence