HCID 10712597, compound → HCID 10816992, compound

Participants

Reaction Steps

The title compound was prepared from 3-methyl-(2S)-2-[4-(4-oxo-piperidin-1-yl)-benzoylamino]-butyric acid ethyl ester (which was obtained in Example 163) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 180 as an off-white solid; mp>85° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 0.92 (d, J=6.8 Hz, 3 H), 0.97 (d, J=6.8 Hz, 3 H), 1.17 (t, J=7.1 Hz, 3 H), 1.20–1.40 (m, 2 H), 1.75–1.95 (m, 2 H), 2.05–2.20 (m, 1 H), 2.55–2.90 (m, 5 H), 2.90 (s, 3 H), 3.70–3.85 (m, 2 H), 4.00–4.20 (m, 2 H), 4.22 (t, J=7.7 Hz, 1 H), 4.48 (dd, J=8.0, 4.4 Hz, 1 H), 6.80 (d, J=8.2 Hz, 1 H), 6.95 (d, J=8.9 Hz, 2 H), 6.98 (dd, J=8.2, 2.0 Hz, 1 H), 7.17 (d, J=2.0 Hz, 1 H), 7.76 (d, J=8.9 Hz, 2 H), 8.17 (d, J=7.9 Hz, 1 H); MS (ES) m/z: 577.2 (MH+); HRMS Calcd. for C29H43N4O7S (MH+): 577.2690. Found: 577.2682.

Provenance & Evidence