Sodium Hydroxide → HCID 10602703, compound

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Reaction Steps

The title compound was prepared from (2S)-2-(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-3-methyl-butyric acid ethyl ester (which was obtained in Example 202) by sodium hydroxide hydrolysis as a pale yellowish solid; mp>135° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 0.90 (d, J=2.3 Hz, 3 H), 0.92 (d, J=2.3 Hz, 3 H), 1.45–1.55 (m, 2 H), 1.90–2.05 (m, 2 H), 2.05–2.20 (m, 1 H), 2.60–2.94 (m, 5 H), 2.94 (s, 3 H), 3.70–3.85 (m, 2 H), 4.11 (t, J=6.0 Hz, 1 H), 4.65–4.75 (m, 1 H), 6.86 (d, J=8.3 Hz, 1 H), 6.91 (d, J=8.9 Hz, 2 H), 7.06 (dd, J=8.3, 2.0 Hz, 1 H), 7.22 (d, J=2.0 Hz, 1 H), 7.65–7.75 (m, 3 H); MS (ES) m/z: 549.3 (MH+); HRMS Calcd. for C26H35N4O7S (M−H)−: 547.2231. Found: 547.2229.

Provenance & Evidence