Sodium Hydroxide → HCID 10651147, compound

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Reaction Steps

The title compound was prepared from (2S)-2-(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-benzoylamino)-3-phenyl-propionic acid methyl ester (which was obtained in Example 204) by sodium hydroxide hydrolysis as a pale yellowish solid; mp>160° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.50 (m, 2 H), 1.90–2.05 (m, 2 H), 2.50–3.50 (m, 7 H), 2.95 (s, 3 H), 3.69–3.75 (m, 2 H), 4.30–4.45 (m, 2 H), 4.70–4.75 (m, 1 H), 6.83 (d, J=8.8 Hz, 2 H), 6.88 (d, J=8.3 Hz, 1 H), 7.05–7.30 (m, 7 H), 7.63 (d, J=8.8 Hz, 2 H), 7.93 (br d, J=6.6 Hz, 1 H); MS (ES) m/z: 597.1 (MH+); HRMS Calcd. for C30H35N4O7S (M−H)−: 595.2231. Found: 595.2232.

Provenance & Evidence