Acetic Acid → HCID 69655025, compound

Participants

Reaction Steps

A solution of 0.10 g (0.2 mmol) of (E)-3-(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-piperidin-1-yl}-phenyl)-acrylic acid ethyl ester (which was obtained in Example 183) in ethanol (3 mL) was treated with 3 mL of 1 N NaOH. After 18 h at room temperature, the mixture was acidified with acetic acid. The resulting suspension was filtered and the precipitate was washed with water, and dried in vacuo to give 0.09 g of a tan solid; m.p. 220° C.; 1H NMR (DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.80–1.95 (m, 2 H), 2.57–2.95 (m, 5 H), 2.92 (t, 3 H), 3.74–3.82 (m, 2 H), 4.48–4.52 (m, 1 H), 6.22 (s, 1 H), 6.27 (s, 1 H), 6.81–7.03 (m, 4 H), 7.18 (d, 1 H), 7.42–7.49 (m, 3 H)); MS (ES) m/z: 476.0 (MH+).

Provenance & Evidence