反应详情

The title compound was prepared from 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-phenylamine (which was obtained in Example 214) and 4-methoxybenzenesulfonyl chloride according to the procedure of Example 215 as a crystalline solid; 1H NMR (300 MHz, DMSO-d6) δ 1.65 (t, J=5.6 Hz, 4 H), 3.15 (t, J=5.6 Hz, 4 H), 3.79 (s, 3 H), 3.88 (s, 4 H), 6.69 (d, J=9.0 Hz, 2 H), 9.63 (s, 1 H); MS (ES) m/z: 405.3 (MH+); HRMS Calcd. for C20H24N2O5S (M+): 404.1406. Found: 404.1402. Anal. Calcd. for C20H24N2O5S: C, 59.39; H, 5.98; N, 6.93. Found: C, 59.48; H, 6.03; N, 6.85.