4-(3-Hexyl-ureido)benzenesulfonyl chloride → N-[4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-phenyl]-4-(3-hexyl-ureido)-benzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-phenylamine (which was obtained in Example 214) and 4-(3-hexyl-ureido)benzenesulfonyl chloride (U.S. Pat. No. 5,561,142/1996) according to the procedure of Example 215 as a white flake; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=6.5 Hz, 3 H), 1.20–1.50 (m, 8 H), 1.65 (t, J=5.7 Hz, 4 H), 3.00–3.10 (m, 2 H), 3.14 (t, J=5.7 Hz, 4 H), 3.88 (s, 4 H), 6.28 (t, J=5.6 Hz, 1 H), 6.79 (d, J=9.0 Hz, 2 H), 6.87 (d, J=9.0 Hz, 2 H), 7.45 (d, J=9.1 Hz, 2 H), 7.51 (d, J=9.1 Hz, 2 H), 8.82 (s, 1 H); MS (ES) m/z: 517.2 (MH+); HRMS Calcd. for C26H37N4O5S (MH+): 517.2485. Found: 517.2377. Anal. Calcd. for C26H36N4O5S: C, 60.44; H, 7.02; N, 10.84. Found: C, 60.29; H, 6.95; N, 10.91.

Provenance & Evidence