1-Butanesulfonyl chloride → N-[4-(4-Oxo-1-piperidinyl)phenyl]-1-butanesulfonamide

Participants

Reaction Steps

The title compound was prepared from 1-butanesulfonyl chloride and 1-(4-amino-phenyl)-piperidin-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a crystalline solid; 1H NMR (300 MHz, DMSO-d6) δ 0.83 (t, J=7.3 Hz, 3 H), 1.25–1.40 (m, 2 H), 1.55–1.70 (m, 2 H), 2.40 (t, J=5.9 Hz, 4 H), 2.94 (t, J=7.6 Hz, 2 H), 3.54 (t, J=5.9 Hz, 4 H), 7.00 (d, J=9.0 Hz, 2 H), 7.09 (d, J=9.0 Hz, 2 H), 9.34 (s, 1 H); MS (ES) m/z: 311.0 (MH+); HRMS Calcd. for C15H22N2O2S(M+): 310.1351. Found: 310.1375. Anal. Calcd. for C15H22N2O2S: C, 58.04; H, 7.14; N, 9.02. Found: C, 57.78; H, 6.95; N, 8.83.

Provenance & Evidence