1-(4-Amino-phenyl)-piperidin-4-one hydrochloride → 5-(5-Trifluoromethyl-pyridin-2-sulfonyl)-thiophene-2-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide

Participants

Reaction Steps

The title compound was prepared from 5-(5-trifluoromethyl-pyridin-2-sulfonyl)-thiophene-2-sulphonyl chloride and 1-(4-amino-phenyl)-piperidin-4-one (which was obtained in Example 224) according to the procedure B of Example 225 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 2.37 (t, J=4.5 Hz, 4 H), 3.52 (t, J=4.5 Hz, 4 H), 6.90–7.10 (m, 4 H), 7.90 (d, J=1.2 Hz, 1 H), 8.41 (d, J=6.3 Hz, 1 H), 8.50 (d, J=1.2 Hz, 1 H), 8.62 (dd, J=6.3, 1.5 Hz, 1 H), 9.23 (s, 1 H), 9.89 (s, 1 H); MS (ES) m/z: 545.9 (MH+); HRMS Calcd. for C21H19F3N3O5S3 (MH+): 546.0439. Found: 546.0466. Anal. Calcd. for C21H18F3N3O5S3: C, 46.23; H, 3.33; N, 7.70. Found: C, 46.46; H, 3.39; N, 7.35.

Provenance & Evidence