1-(4-Amino-phenyl)-piperidin-4-one hydrochloride → {4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenoxy}-acetic acid methyl ester

HRID 1794853Notes

Reaction equation

HRID 1794853 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.Cl.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][C:28](=[O:31])[CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](=[O:14])(=[O:13])[NH:18][C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:26][CH2:27][C:28](=[O:31])[CH2:29][CH2:30]3)=[CH:21][CH:20]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 222202401-(4-Amino-phenyl)-piperidin-4-one hydrochlorideHCID 22479292Methyl 2-[4-(chlorosulfonyl)phenoxy]acetate

Product 1

HCID 69654907{4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenoxy}-acetic acid methyl ester

Procedure

The title compound was prepared from (4-chlorosulfonyl-phenoxy)-acetic acid methyl ester (Chem. Pharm. Bull. 1995, 43, 1132) and 1-(4-amino-phenyl)-piperidin-4-one hydrochloride (which was obtained in Example 224) according to the procedure B of Example 225 as a grey solid; MS (ES) m/z: 418.9 (MH+); HRMS Calcd. for C20H23N2O6S (MH+): 419.1271. Found: 419.1271.

Sources & evidence

ORD record
ord-cc4b5237d91e4ba98188ee94ade9b605
Source dataset
uspto-grants-2006_04
Patent number
US07022716B2

Reaction notes

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