Benzyl bromoacetate → {(Butane-1-sulfonyl)-[4-(4-oxo-piperidin-1-yl)-phenyl]-amino}-acetic acid benzyl ester

Participants

Role	Name	HCID	Charge
Reactant	Benzyl bromoacetate	HCID 62576	—
Reactant	N-[4-(4-Oxo-1-piperidinyl)phenyl]-1-butanesulfonamide	HCID 86584570	—
Product	{(Butane-1-sulfonyl)-[4-(4-oxo-piperidin-1-yl)-phenyl]-amino}-acetic acid benzyl ester	HCID 69655032	—

Reaction Steps

The title compound was prepared from butane-1-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide (which was obtained in Example 228) and benzyl-2-bromoacetate according to the procedure of Example 251 as an orange oil; 1H NMR (300 MHz, CDCl3) δ 0.91 (t, J=7.29 Hz, 3H), 1.34–1.47 (m, 2H), 1.75–1.86 (m, 2H), 2.55 (t, J=6.09 Hz, 4H), 3.17–3.23 (m, 2H), 3.62 (t, J=6.00 Hz, 4H), 4.45 (s, 2H), 5.18 (s, 2H), 6.87–6.92 (m, 2H), 7.30–7.40 (m, 7H); MS (ES) m/z: 459.0 (MH+); HRMS found for C24H30N2O5S: 459.1944.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07022716B2
Source dataset	uspto-grants-2006_04
ORD ID	ord-f0dc7735cbdb49349e4d4376b4bd145b
Source note	uspto-grants-2006_04