4-Methoxy-N-[4-(4-oxo-piperidin-1-yl)-phenyl]benzenesulfonamide → N-[4-(4-{[(2R)-2-Hydroxy-2-phenylethyl]amino}-1-piperidineyl)phenyl]-4-methoxybenzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-methoxy-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 218) and (1R)-2-amino-1-(3-chloro-phenyl)-ethanol hydrochloride (which was obtained in Example 1) according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.55–1.75 (m, 2 H), 2.05–2.15 (m, 2 H), 2.50–3.10 (m, 5 H), 3.50–3.70 (m, 2 H), 3.79 (s, 3 H), 4.90–5.05 (m, 1 H), 6.10–6.20 (m, 1 H), 6.79 (d, J=9.0 Hz, 2 H), 6.89 (d, J=9.0 Hz, 2 H), 7.05 (d, J=11.8 Hz, 2 H), 7.25–7.50 (m, 5 H), 7.60 (d, J=11.8 Hz, 2 H), 9.70 (brs, 1 H); MS (ES) m/z: 482.2 (MH+); HRMS Calcd. for C26H32N3O4S (MH+): 482.2114. Found: 482.2120.

Provenance & Evidence