Norfenefrine → n-(4-{[2-(4-{[2-Hydroxy-2-(3-hydroxyphenyl)ethyl]amino}-1-piperidineyl)anilino]-sulfonyl}phenyl)acetamide

Participants

Reaction Steps

The title compound was prepared from N-{4-[2-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide (which was obtained in Example 222) and DL-norphenylephrine according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.70–1.90 (m, 2 H), 1.90–2.10 (m, 2 H), 2.06 (s, 3 H), 2.50–3.20 (m, 7 H), 4.75–4.95 (m, 1 H), 6.10 (brs, 1 H), 6.50–7.40 (m, 8 H), 7.65–7.80 (m, 4 H), 9.48 (s, 1 H), 10.42 (s, 1 H); MS (ES) m/z: 525.6 (MH+); HRMS Calcd. for C27H33N4O5S (MH+): 525.2172. Found: 525.2164.

Provenance & Evidence