4-((2S)-3-Amino-2-hydroxy-propoxy)-phenol → HCID 69654589, compound

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Reaction Steps

The title compound was prepared from N-{4-[4-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide (which was obtained in Example 216) and (2S)-1-amino-3-(4-hydroxy-phenoxy)-propan-2-ol (which was obtained in Example 5) according to the procedure of Example 255 as a grey solid; 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.65 (m, 2 H), 1.95–2.15 (m, 2 H), 2.06 (s, 3 H), 2.50–3.20 (m, 5 H), 3.55–3.70 (m, 2 H), 3.80–3.90 (m, 1 H), 4.05–4.20 (m, 1 H), 5.70 (brs, 1 H), 6.67 (d, J=9.0 Hz, 2 H), 6.76 (d, J=9.0 Hz, 2 H), 6.78 (d, J=9.0 Hz, 2 H), 6.88 (d, J=9.0 Hz, 2 H), 7.58 (d, J=9.0 Hz, 2 H), 7.69 (d, J=9.0 Hz, 2 H), 8.97 (s, 1 H), 10.37 (s, 1 H); MS (ES) m/z: 555.1 (MH+); HRMS Calcd. for C28H35N4O6S (MH+): 555.2277. Found: 555.2267.

Provenance & Evidence