2-Amino-1-(6-methylpyridin-3-yl)ethanol → 4-{[(Hexylamino)carbonyl]amino}-N-[4-(4-{[2-hydroxy-2-(6-methyl-3-pyridinyl)ethyl]amino}-1-piperidineyl)phenyl]benzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 225) and 2-amino-1-(6-methyl-pyridin-3-yl)ethanol according to the procedure of Example 255 as a grey solid; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=6.8 Hz, 3 H), 1.20–3.30 (m, 19 H), 2.45 (s, 3 H), 3.50–3.75 (m, 2 H), 4.70–4.80 (m, 1 H), 6.41 (t, J=5.5 Hz, 1 H), 6.78 (d, J=9.1 Hz, 2 H), 6.87 (d, J=9.1 Hz, 2 H), 7.21(d, J=8.0 Hz, 1 H), 7.46(d, J=9.2 Hz, 2 H), 7.48(d, J=9.2 Hz, 2 H), 7.64(dd, J=8.0, 2.0 Hz, 1 H), 8.43(d, J=2.0 Hz, 1 H), 9.00 (s, 1 H), 9.50 (brs, 1 H), 11.10 (s, 1 H); MS (ES) m/z: 609.3 (MH+); HRMS Calcd. for C32H45N6O4S (MH+): 609.3223. Found: 609.3235.

Provenance & Evidence