(2S)-(-)-1-Amino-3-phenoxy-2-propanol → N-(4-{[4-(4-{[(2S)-2-Hydroxy-3-phenoxypropyl]amino}-1-piperidineyl)anilino]-sulfonyl}phenyl)acetamide

Participants

Reaction Steps

The title compound was prepared from N-{4-[4-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide (which was obtained in Example 216) and (2S)-1-amino-3-phenoxy-propan-2-ol (which was obtained in Example 3) according to the procedure of Example 255 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.65 (m, 2 H), 1.95–2.10 (m, 2 H), 2.06 (s, 3 H), 2.50–3.20 (m, 5 H), 3.55–3.75 (m, 2 H), 3.96 (d, J=5.2 Hz, 2 H), 4.15–4.25 (m, 1 H), 5.70(brs, 1 H), 6.80 (d, J=9.0 Hz, 2 H), 6.88 (d, J=9.0 Hz, 2 H), 6.90–7.00 (m, 3 H), 7.25–7.35 (m, 2 H), 7.59 (d, J=9.0 Hz, 2 H), 7.69 (d, J=9.0 Hz, 2 H), 9.70 (s, 1 H), 10.37 (s, 1 H), MS (ES) m/z: 539.1 (MH+); HRMS Calcd. for C28H35N4O5S (MH+): 539.2328. Found: 539.2357.

Provenance & Evidence