4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide → 4-{[(Hexylamino)carbonyl]amino}-N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}phenyl)benzenesulfonamide

Participants

Reaction Steps

The title compound was prepared from 4-(3-hexyl-ureido)-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 225) and N-[2-benzyloxy-5-(2-amino-(1R)-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (which was obtained in Example 8) according to the procedure of Example 255 as a grey solid; 1H NMR (300 MHz, DMSO-d6) δ 0.86 (t, J=6.9 Hz, 3 H), 1.20–1.80 (m, 10 H), 1.95–2.15 (m, 2 H), 2.50–3.30 (m, 7 H), 2.97 (s, 3 H), 3.55–3.70 (m, 2 H), 4.70–4.85 (m, 1 H), 5.90–6.10 (m, 1 H), 6.48 (t, J=5.6 Hz, 1 H), 6.83 (d, J=9.2 Hz, 2 H), 6.90 (d, J=9.2 Hz, 2 H), 6.91 (d, J=8.4 Hz, 1 H), 7.07(dd, J=8.4, 2.0 Hz, 1 H), 7.24 (d, J=2.0 Hz, 1 H), 7.46(d, J=9.2 Hz, 2 H), 7.51(d, J=9.2 Hz, 1 H), 8.50–8.90 (brs, 1 H), 9.39 (s, 1 H), 9.61 (s, 1 H); MS (ES) m/z: 703.4 (MH+); HRMS Calcd. for C33H47N6O7S2(MH+): 703.2948. Found: 703.2946.

Provenance & Evidence