N-{4-[4-(4-Oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide → N-{4-[(4-{4-[((2R)-2-Hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]-phenyl}ethyl)amino]-1-piperidineyl}anilino)sulfonyl]phenyl}acetamide

Participants

Reaction Steps

The title compound was prepared from N-{4-[4-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-phenyl}-acetamide (which was obtained in Example 216) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-benzyloxy-phenyl]-methanesulfonamide (which was obtained in Example 8) according to the procedure of Example 255 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.70 (m, 2 H), 1.90–2.10 (m, 2 H), 2.06 (s, 3 H), 2.50–2.65 (m, 2 H), 2.90–3.15 (m, 3 H), 2.94 (s, 3 H), 3.55–3.70 (m, 2 H), 4.65–4.80 (m, 1 H), 6.79 (d, J=9.0 Hz, 2 H), 6.97 (d, J=9.0 Hz, 2 H), 7.00 (d, J=8.0 Hz, 1 H), 7.06 (dd, J=8.0, 1.2 Hz, 1 H), 7.22 (d, J=1.2 Hz, 1 H), 7.40 (d, J=8.7 Hz, 2 H), 7.69 (d, J=8.7 Hz, 2 H), 10.42 (s, 1 H), 10.44 (s, 1 H); MS (ES) m/z: 618.0 (MH+); HRMS Calcd. for C28H36N5O7S2 (MH+): 618.2056. Found: 618.2056.

Provenance & Evidence