N-[2-Benzyloxy-5-(2-dibenzylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide → N-(4-{4-[(2-Hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}phenyl)-1-butanesulfonamide

Participants

Reaction Steps

The title compound was prepared from butane-1-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide (which was obtained in Example 228) and N-[2-benzyloxy-5-(2-dibenzylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (which was obtained in Example 7) according to the procedure of Example 255 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.83(t, J=7.2 Hz, 3 H), 1.20–1.40 (m, 2 H), 1.50–1.70 (m, 4 H), 1.95–2.10 (m, 2 H), 2.40–2.60 (m, 2 H), 2.94 (s, 3 H), 2.90–3.20 (m, 5 H), 3.62–3.75 (m, 2 H), 4.70–4.80 (m, 1 H), 5.95 (brs, 1 H), 6.85–6.95 (m, 3 H), 7.00–7.10 (m, 3 H), 7.24 (d, J=2.0 Hz, 1 H), 8.70 (brs, 1 H), 9.33 (brs, 1 H); MS (ES) m/z: 541.0 (MH+); HRMS Calcd. for C24H37N4O6S2 (MH+): 541.2155. Found: 541.2161.

Provenance & Evidence