N-[2-Benzyloxy-5-(2-dibenzylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide → N-(4-{4-[(2-Hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}phenyl)-1-octanesulfonamide

Participants

Reaction Steps

The title compound was prepared from octane-1-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide (which was obtained in Example 230) and N-[2-benzyloxy-5-(2-dibenzylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide (which was obtained in Example 7) according to the procedure of Example 255 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.84(t, J=7.0 Hz, 3 H), 1.15–1.40 (m, 12 H) 1.50–1.70 (m, 2 H), 1.80–1.95 (m, 2 H), 2.50–2.92 (m, 7 H), 3.50–3.65 (m, 2 H), 4.49 (dd, J=8.0, 4.1 Hz, 1 H), 6.82 (d, J=8.3 Hz, 1 H), 6.88 (d, J=8.0 Hz, 2 H), 7.00 (dd, J=8.3, 2.0 Hz, 1 H), 7.04 (d, J=8.0 Hz, 2 H), 7.17 (d, J=2.0 Hz, 1 H); MS (ES) m/z: 597.1 (MH+); HRMS Calcd. for C28H45N4O6S2 (MH+): 597.2781. Found: 597.2776.

Provenance & Evidence