N-[5-((2S)-3-Amino-2-hydroxy-propoxy)-2-hydroxy-phenyl]-methanesulfonamide → N-(4-{4-[((2S)-2-Hydroxy-3-{4-hydroxy-3-[(methylsulfonyl)amino]phenoxy}-propyl)amino]-1-piperidineyl}phenyl)-1-butanesulfonamide

Participants

Reaction Steps

The title compound was prepared from butane-1-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide (which was obtained in Example 228) and N-[5-((2S)-3-amino-2-hydroxy-propoxy)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 14) according to the procedure of Example 278 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.83 (t, J=7.3 Hz, 3 H), 1.25–1.40 (m, 2 H), 1.55–1.70 (m, 2 H), 1.80–1.95 (m, 2 H), 2.50–2.80 (m, 5 H), 2.92 (s, 3 H), 2.85–3.30 (m, 2 H), 3.50–3.65 (m, 2 H), 3.70–3.90 (m, 3 H), 6.61 (dd, J=8.8, 2.9 Hz, 1 H), 6.70–6.80 (m, 2 H), 6.88 (d, J=8.9 Hz, 2 H), 7.05 (d, J=8.9 Hz, 2 H); MS (ES) m/z: 571.0 (MH+); HRMS Calcd. for C25H39N4O7S2 (MH+): 571.2261. Found: 571.2279.

Provenance & Evidence