N-[4-(4-Oxo-1-piperidinyl)phenyl]-1-butanesulfonamide → HCID 69654685, compound

Participants

Reaction Steps

The title compound was prepared from butane-1-sulfonic acid [4-(4-oxo-piperidin-1-yl)-phenyl]-amide (which was obtained in Example 228) and propane-2-sulfonic acid [5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-amide (which was obtained in Example 27) according to the procedure of Example 278 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 0.83 (t, J=7.3 Hz, 3 H), 1.20–1.40 (m, 4 H), 1.25 (d, J=6.8 Hz, 6 H), 1.55–1.75 (m, 2 H), 1.75–1.90 (m, 2 H), 2.50–2.75 (m, 5 H), 2.92 (t, J=7.7 Hz, 2 H), 3.05–3.15 (m, 1 H), 3.45–3.60 (m, 2 H), 4.46 (dd, J=7.8, 4.5 Hz, 1 H), 6.78 (d, J=8.2 Hz, 1 H), 6.88 (d, J=9.0 Hz, 2 H), 6.96 (dd, J=8.2, 2.0 Hz, 1H), 7.04 (d, J=9.0 Hz, 2 H), 7.23 (d, J=2.0 Hz, 1 H); MS (ES) m/z: 569.0 (MH+); HRMS Calcd. for C26H41N4O6S2 (MH+): 569.2462. Found: 569.2458.

Provenance & Evidence