(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 69654864, compound

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Reaction Steps

The title compound was prepared from 3-[4-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-thiophene-2-carboxylic acid methyl ester (which was obtained in Example 234) and N-[5-((1 R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 278 as a pale yellowish solid; 1H NMR (300 MHz, DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.70–1.90 (m, 2 H), 2.50–2.75 (m, 5 H), 3.40–3.55 (m, 2 H), 3.89 (s, 2 H), 4.46 (dd, J=8.0, 4.2 Hz, 1 H), 6.75–6.85(m, 3 H), 6.90 (d, J=9.0 Hz, 2 H), 7.00 (dd, J=8.3, 2.0 Hz, 1 H), 7.16 (d, J=2.0 Hz, 1 H), 7.32 (d, J=3.3 Hz, 1 H), 7.89 (d, J=3.3 Hz, 1 H); MS (ES) m/z: 624.9 (MH+); HRMS Calcd. for C26H34N4O8S3 (MH+): 625.1455. Found: 625.1441.

Provenance & Evidence