Sodium Hydroxide → HCID 69654956, compound

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Reaction Steps

The title compound was prepared from methyl 3-[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)sulfonyl]-2-thiophenecarboxylate (which was obtained in Example 320) by NaOH hydrolysis as a pale grey solid; 1H NMR (300 MHz, DMSO-d6) δ 1.50–1.70 (m, 2 H), 1.95–2.10 (m, 2 H), 2.50–2.70 (m, 2 H), 2.95 (s, 3 H), 3.00–3.30 (m, 3 H), 3.60–3.70 (m, 2 H), 4.75–4.85 (m, 1 H), 6.10 (brs, 1 H), 6.80 (d, J=9.0 Hz, 2 H), 6.85–6.95(m, 3 H) 7.04 (d, J=5.4 Hz, 1 H), 7.08 (dd, J=8.4, 1.8 Hz, 1 H), 7.26 (d, J=1.8 Hz, 1 H), 7.39 (d, J=5.4 Hz, 1 H), 8.73 (brs, 1 H), 9.96 (brs, 1 H); MS (ES) m/z: 610.7 (MH+); HRMS Calcd. for C25H31N4O8S3 (MH+): 611.1299. Found: 611.1284.

Provenance & Evidence