(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 69654723, compound

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Reaction Steps

The title compound was prepared from [4-(4-oxo-piperidin-1-yl)-phenylsulfamoyl]-acetic acid benzyl ester (which was obtained in Example 236) and N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 10) according to the procedure of Example 255 as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.40–1.60 (m, 2 H), 1.90–2.05 (m, 2 H), 2.50–2.90 (m, 5 H), 2.94 (s, 3 H), 3.50–3.65 (m, 2 H), 4.65–4.75 (m, 1 H), 6.80–6.90 (m, 3 H), 7.00–7.10 (m, 3 H), 7.23 (d, J=2.0 Hz, 1 H); MS (ES) m/z: 543.3 (MH+); HRMS Calcd. for C29H37N4O8S2(MH+): 543.1578. Found: 543.1572.

Provenance & Evidence