(2S)-(-)-1-Amino-3-phenoxy-2-propanol → HCID 69654709, compound

HRID 1794914Notes

Reaction equation

HRID 1794914 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[Cl:16][C:17]1[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[CH:33]=[CH:32][C:18]=1[O:19][C:20]1[C:25]([Cl:26])=[CH:24][C:23]([S:27](Cl)(=[O:29])=[O:28])=[CH:22][C:21]=1[Cl:31].[NH2:39][CH2:40][C@H:41]([OH:50])[CH2:42][O:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1>>[Cl:31][C:21]1[CH:22]=[C:23]([S:27]([NH:2][C:3]2[CH:8]=[CH:7][C:6]([N:9]3[CH2:14][CH2:13][CH:12]([NH:39][CH2:40][C@H:41]([OH:50])[CH2:42][O:43][C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[CH2:11][CH2:10]3)=[CH:5][CH:4]=2)(=[O:29])=[O:28])[CH:24]=[C:25]([Cl:26])[C:20]=1[O:19][C:18]1[CH:32]=[CH:33][C:34]([N+:36]([O-:38])=[O:37])=[CH:35][C:17]=1[Cl:16]

Participants

4

Reactant 3

HCID 1133101(2S)-(-)-1-Amino-3-phenoxy-2-propanolHCID 27743613,5-Dichloro-4-(2-chloro-4-nitrophenoxy)benzene-1-sulfonyl chlorideHCID 222202401-(4-Amino-phenyl)-piperidin-4-one hydrochloride

Product 1

HCID 69654709HCID 69654709, compound

Procedure

The title compound was prepared from 1-(4-aminophenyl)-4-piperidone hydrochloride (which was obtained in Example 224), 4-(2-chloro-4-nitrophenoxy)-3,5-dichlorobenzenesulfonyl chloride, and (2S)-1-amino-3-phenoxy-propan-2-ol according to the procedure of Example 346; MS (ES) m/z: 723.2, 725.2 (MH+).

Sources & evidence

ORD record
ord-848f306909024706b4bc9604e97a9f56
Source dataset
uspto-grants-2006_04
Patent number
US07022716B2

Reaction notes

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