反应详情

The title compound was prepared from ethyl {[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}anilino)carbonyl]-amino}acetate (which was obtained in Example 377) by NaOH hydrolysis as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.35–1.55 (m, 2 H), 1.80–2.00 (m, 2 H), 2.50–2.90 (m, 5 H), 2.92 (s, 3 H), 3.30–3.50 (m, 2 H), 3.59 (d, J=5.9 Hz, 2 H), 4.60 (dd, J=8.8, 3.5 Hz, 1 H), 6.14 (t, J=5.0 Hz, 1 H), 6.80 (d, J=9.1 Hz, 2 H), 6.84 (d, J=8.3 Hz, 1 H), 7.03 (dd, J=8.3, 2.0 Hz, 1 H), 7.15–7.25 (m, 3 H), 8.54 (s, 1 H); MS (ES) m/z: 520.3 (M−H)−; HRMS Calcd. for C23H32N5O7S (MH+): 522.2017. Found: 522.2000.