Water → HCID 86584578, compound

Participants

Reaction Steps

1-(4-Nitro-phenyl)-azetidin-3-ol (which was obtained in Example 396) (5.0 g, 25.8 mmol) was added to a solution of methanesulfonyl chloride (2.2 mL, 28.3 mmol) in dry pyridine (35 mL) and stirred at room temperature overnight. Water was added and the resultant precipitate was captured on a filter, washed with water, methanol, and hexanes to give 3.72 g of the desired product as an orange solid; 1H NMR (DMSO-d6) δ3.35 (s, 3H), 4.15(m, 3H), 4.45(m, 2H), 5.48(m, 1H), 6.53(d, 2H, J=9.12 Hz), 8.09(d, 2H, J=9.12 Hz); MS (ES) m/z: 273.5 (MH+); Anal. Calcd. for C10H12N2O5S: C, 44.11; H, 4.44; N, 10.29. Found: C, 44.50; H, 4.48; N, 10.64.

Provenance & Evidence