反应详情

N-(2-Aminoethyl)-alanine ethyl ester 2HCl (1.165 g, 5.0 mmol), prepared as described by Puschl (A. Puschl et al., Tetrahedron, 1998, 39, 4707–4710.), was reacted with 2-nitro-benzenesulfonyl chloride (1.11 g 5.0 mmol) as per the procedure of example 13 to give the title compound (1.64 g, 95%). 1H-NMR (500 MHz; DMSO-d6) δ 8.02˜7.96 (m, 2H), 7.86 (m, 2H), 4.05 (q, 2H), 3.16 (q, 1H), 2.94 (t, 2H), 2.58 (m, 1H), 2.43 (m, 1H), 1.17 (t, 3H), 1.09 (d, 3H).