Hydrochloric Acid → HCID 22222406, compound

Participants

Reaction Steps

To a suspension of [2-(benzyloxycarbonyl)-amino-6-iodo-purine-9-yl]-acetic acid ethyl ester (10.02 g, 20.8 mmol) in tetrahydrofuran (50 mL) and water (50 mL) was added lithium hydroxide hydrate (2.83 g, 20.8 mmol) at 10° C. The resulting reaction mixture was stirred for 30 min. Then the mixture was acidified to pH=3 by adding 1N HCl. The precipitated solid was filtered off, washed with water and ethyl ether, and dried in vacuo to give the title compound (9.81 g). 1H-NMR (500 MHz; DMSO-d6) δ 10.75 (s, 1H), 8.44 (s, 1H), 7.50˜7.30 (m, 5H), 5.17 (s, 2H), 4.97 (s, 2H).

Provenance & Evidence