2-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acid → HCID 22222433, compound

HRID 1794951Notes

Reaction equation

HRID 1794951 reaction equation
Cl.[N+:2]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[S:15]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][C:19]1=[O:24])(=[O:17])=[O:16])([O-:4])=[O:3].[N:25]1([CH2:34][C:35](O)=[O:36])[CH:33]=[C:31]([CH3:32])[C:29](=[O:30])[NH:28][C:26]1=[O:27]>>[N+:2]([C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:6]=1[S:15]([N:18]1[CH2:23][CH2:22][N:21]([C:35](=[O:36])[CH2:34][N:25]2[CH:33]=[C:31]([CH3:32])[C:29](=[O:30])[NH:28][C:26]2=[O:27])[CH2:20][C:19]1=[O:24])(=[O:17])=[O:16])([O-:4])=[O:3]

Participants

3

Reactant 2

HCID 8537532-(5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetic acidHCID 68798537HCID 68798537, compound

Product 1

HCID 22222433HCID 22222433, compoundYield 94.3%

Procedure

The title compound (980 mg, 94%) was synthesized by reaction of 1-(2-nitro-4-trifluoromethyl-benzenesulfonyl)-piperazin-2-one HCl salt (780 mg, 2 mmol) with (thymin-1-yl)-acetic acid (369 mg, 2 mmol) as per the procedure of example 64.

Sources & evidence

ORD record
ord-d0da1d5652d94bacbe1ee4ad1667944e
Source dataset
uspto-grants-2006_04
Patent number
US07022851B2

Reaction notes

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