反应详情

The title compound (1.32 g, 60%) was synthesized by reaction of 1-(4-chloro-2-nitro-benzenesulfonyl)-piperazin-2-one HCl salt (1.25 g, 3.5 mmol) with [2-N-(benzyloxycarbonyl)-guanin-9-yl]-acetic acid (1.15 g, 3.5 mmol) as per the procedure of example 82. 1H NMR (DMSO-d6): δ 11.46 (s, 1H), 11.37 (s, 1H), 8.44˜8.31 (m, 2H), 8.09 (m, 1H), 7.82 (s, 0.6H), 7.78 (s, 0.4H), 7.46˜7.33 (m, 5H), 5.25 (s, 2H), 5.12 (s, 1.2H), 5.04 (s, 0.8H), 4.51 (s, 0.8H), 4.26 (s, 1.21H), 4.10˜4.00 (m, 2.4H), 3.92˜3.82 (m, 1.6H).