1-Acetylpiperazine → HCID 9960686, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-[3,5-bis(trifluoromethyl)benzyl]-9-chloro-7-(2-methylphenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (compound of Reference Example 17; 100 mg) and 1-acetylpiperazine (73.0 mg) was stirred at 150° C. for 5 hours. To the resulting residue, water was added, and then the mixture was subjected to extraction with ethyl acetate. The resulting extract was dried on anhydrous sodium sulfate. The solvent was removed by distillation to obtain a residue, and then the residue was purified on silica gel column chromatography (ethyl acetate: methanol=10:1) to obtain 9-(4-acetylpiperazine-1-yl)-5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (44.6 mg, 38%).

Provenance & Evidence