1-Acetylpiperazine → HCID 22184433, compound

HRID 1795009Notes

Reaction equation

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:6][N:7]1[C:13](=[O:14])[C:12]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])=[CH:16][C:17](Cl)=[N:18][C:11]=2[O:10][CH2:9][CH2:8]1.[C:36]([N:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1)(=[O:38])[CH3:37]>>[C:36]([N:39]1[CH2:44][CH2:43][N:42]([C:17]2[CH:16]=[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[CH3:26])[C:12]3[C:13](=[O:14])[N:7]([CH2:6][C:5]4[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=[C:3]([C:2]([F:1])([F:35])[F:34])[CH:4]=4)[CH2:8][CH2:9][O:10][C:11]=3[N:18]=2)[CH2:41][CH2:40]1)(=[O:38])[CH3:37]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 22179322HCID 22179322, compound

Product 1

HCID 22184433HCID 22184433, compoundYield 10%

Procedure

In a similar manner to Example 1, 4-[3,5-bis(trifluoromethyl)benzyl]-8-chloro-6-(2-methylphenyl)-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (compound of Reference Example 19; 51.5 mg) was reacted with 1-acetylpiperazine (38.5 mg) to obtain 8-(4-acetylpiperazine-1-yl)-4-[3,5-bis(trifluoromethyl)benzyl]-6-(2-methylphenyl)-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (6.0 mg, 10%).

Sources & evidence

ORD record: ord-d9d35c1cce6c467989f3e048ab5da2c3
Source dataset: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07026309B2

Reaction notes

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