HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 22184426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Tert-butyl 1,4-diazepane-1-carboxylate | HCID 2756058 | — |
| Reactant | HCID 22179322 | HCID 22179322 | — |
| Product | HCID 22184426 | HCID 22184426 | 11% |
Reaction Steps
In a similar manner to Example 6, 4-[3,5-bis(trifluoromethyl)benzyl]-8-chloro-6-(2-methylphenyl)-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (compound of Reference Erxample 17; 51.5 mg) was reacted with 1-(t-butoxycarbonyl)homopiperazine (50.1 mg) and acetyl chloride (0.1 mL) to obtain 8-(4-acetylhomopiperazine-1-yl)-4-[3,5-bis(trifluoromethyl)benzyl]-6-(2-methylphenyl)-5-oxo-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (6.7 mg, 11%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026309B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-e1b9473ebd464205b8282062750d8570 |
| Source note | uspto-grants-2006_04 |