Methanesulfonyl chloride → HCID 22184435, compound

Participants

Reaction Steps

In a similar manner to Example 6, 5-[3,5-bis(trifluoromethyl)benzyl]-9-chloro-7-(2-methylphenyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (compound of Reference Example 17; 65.0 mg) was reacted with 1-(t-butoxycarbonyl)piperazine (57.5 mg) and methylsulfonyl chloride (50 μL) to obtain 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-9-[4-(methylsulfonyl)piperazine-1-yl]-6-oxo-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (46.7 mg, 58%).

Provenance & Evidence