Dichloromethane → HCID 58619015, compound

Participants

Reaction Steps

To a solution of (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-yl-propan-2-ol (300 mg, 1.0 mmol) in acetone (10 ml) was added allyl bromide (0.130 ml, 1.5 mmol) and potasium carbonate (280 mg, 2.0 mmol). The solution was heated to reflux and stirred for 5 hours. Thin layer chromatography (10:1 dichloromethane:methanol) showed formation of product. The solution was cooled and filtered. The filtrate was concentrated under reduced pressure, and the residue purified by preparative chromatography (10:1 dichloromethane:methanol) to yield (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-(4-prop-2-enylpiperazinyl)propan-2-ol (150 mg, M+1=348.2)

Provenance & Evidence